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{"id":10914,"date":"2023-05-31T18:11:14","date_gmt":"2023-05-31T16:11:14","guid":{"rendered":"https:\/\/test.eneviahealth.com\/?p=10914"},"modified":"2025-01-03T17:00:42","modified_gmt":"2025-01-03T16:00:42","slug":"varicella-virus-efectos-neuropsiquiatricos-ivig","status":"publish","type":"post","link":"https:\/\/test.eneviahealth.com\/en\/blog\/varicella-virus-efectos-neuropsiquiatricos-ivig\/","title":{"rendered":"Varicella a virus that can cause Neuropsychiatric effects and its experimental treatment with Immunoglobulins (IVIG)"},"content":{"rendered":"

The inflammatory autoimmune disorders<\/strong> they can be triggered by viral or bacterial infections in children. Today, we want to talk about a novel concept that has been observed in two pediatric patients: Varicella Neuropsychiatry Associated Syndrome (VANS).<\/p>\n\n\n\n

The first case, a 6-year-old boy, who experienced neuropsychiatric symptoms after a VZV infection.<\/figcaption><\/figure>\n\n\n\n
This syndrome is hypothesized to is the result of autoimmune reactivity<\/strong>, caused by a molecular mimicry between the Varicella Zoster Virus (VZV) and the brain, leading to a post-infectious psychiatric syndrome in children with VZV infections.<\/p>\n\n\n\n
In the two cases presented, children experienced neuropsychiatric symptoms after VZV infection<\/strong>, along with persistent central nervous system inflammation after resolution of the infection, and a modulated immune response. Both cases met the diagnostic criteria for autoimmune etiology of pediatric encephalitis.<\/p>\n\n\n\n
The first case <\/strong>involves a 6-year-old boy who experienced neuropsychiatric symptoms, including anxiety, fear, emotional dysregulation, and visual hallucinations after a VZV infection. In it second case<\/strong>, a 10-year-old girl experienced behavioral disorders, characterized by restlessness, insomnia, uncontrollable crying, thought disturbances, and visual hallucinations, three weeks after contracting chickenpox.<\/p>\n\n\n\n
$\"\"$
In the second case, a 10-year-old girl experienced behavioral disorders.<\/figcaption><\/figure>\n\n\n\n
Immunomodulatory treatments, including intravenous immunoglobulin (IVIG)<\/strong> and **steroids,<\/strong> led to a marked improvement in symptoms, allowing the children to return to school. <\/p>\n\n\n\n**
However, patients did not return to their pre-illness state,<\/strong> experiencing ongoing problems with attention and mood fluctuations. The study suggests that VZV can precipitate an autoimmune response <\/strong>leading to neuropsychiatric syndromes in children, an observation that has not been reported before.<\/p>\n\n\n\n
In the second segment of the study, the researchers point to other cases in which post-infectious psychiatric syndromes have been observed after VZV infection, such as anti-NMDA receptor encephalitis and progressive encephalomyelitis with rigidity and myoclonus (PERM). A common theme in these cases is the significant improvement of the syndromes when treated with **antivirals and intravenous immunomodulatory steroids<\/strong>.<\/p>\n\n\n\n**
**Here is the link to the article:<\/p>\n\n\n\n**
**https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9969201\/<\/a><\/p>","protected":false},"excerpt":{"rendered":"**
Los trastornos autoinmunes inflamatorios pueden ser desencadenados por infecciones virales o bacterianas en ni\u00f1os. Hoy, queremos hablarles de un concepto novedoso que se ha observado en dos pacientes pedi\u00e1tricos: el S\u00edndrome Asociado a la Neuropsiquiatr\u00eda de la Varicella (VANS). Este s\u00edndrome se hipotetiza que es el resultado de la reactividad autoinmune, provocada por una imitaci\u00f3n […]<\/p>\n","protected":false},"author":1530,"featured_media":114119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257],"tags":[],"class_list":["post-10914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sistema-inmune"],"_links":{"self":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/users\/1530"}],"replies":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/comments?post=10914"}],"version-history":[{"count":1,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914\/revisions"}],"predecessor-version":[{"id":114162,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914\/revisions\/114162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/media\/114119"}],"wp:attachment":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/media?parent=10914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/categories?post=10914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/tags?post=10914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

The first case, a 6-year-old boy, who experienced neuropsychiatric symptoms after a VZV infection.<\/figcaption><\/figure>\n\n\n\n
This syndrome is hypothesized to is the result of autoimmune reactivity<\/strong>, caused by a molecular mimicry between the Varicella Zoster Virus (VZV) and the brain, leading to a post-infectious psychiatric syndrome in children with VZV infections.<\/p>\n\n\n\n
In the two cases presented, children experienced neuropsychiatric symptoms after VZV infection<\/strong>, along with persistent central nervous system inflammation after resolution of the infection, and a modulated immune response. Both cases met the diagnostic criteria for autoimmune etiology of pediatric encephalitis.<\/p>\n\n\n\n
The first case <\/strong>involves a 6-year-old boy who experienced neuropsychiatric symptoms, including anxiety, fear, emotional dysregulation, and visual hallucinations after a VZV infection. In it second case<\/strong>, a 10-year-old girl experienced behavioral disorders, characterized by restlessness, insomnia, uncontrollable crying, thought disturbances, and visual hallucinations, three weeks after contracting chickenpox.<\/p>\n\n\n\n
$\"\"$
In the second case, a 10-year-old girl experienced behavioral disorders.<\/figcaption><\/figure>\n\n\n\n
Immunomodulatory treatments, including intravenous immunoglobulin (IVIG)<\/strong> and **steroids,<\/strong> led to a marked improvement in symptoms, allowing the children to return to school. <\/p>\n\n\n\n**
However, patients did not return to their pre-illness state,<\/strong> experiencing ongoing problems with attention and mood fluctuations. The study suggests that VZV can precipitate an autoimmune response <\/strong>leading to neuropsychiatric syndromes in children, an observation that has not been reported before.<\/p>\n\n\n\n
In the second segment of the study, the researchers point to other cases in which post-infectious psychiatric syndromes have been observed after VZV infection, such as anti-NMDA receptor encephalitis and progressive encephalomyelitis with rigidity and myoclonus (PERM). A common theme in these cases is the significant improvement of the syndromes when treated with **antivirals and intravenous immunomodulatory steroids<\/strong>.<\/p>\n\n\n\n**
**Here is the link to the article:<\/p>\n\n\n\n**
**https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9969201\/<\/a><\/p>","protected":false},"excerpt":{"rendered":"**
Los trastornos autoinmunes inflamatorios pueden ser desencadenados por infecciones virales o bacterianas en ni\u00f1os. Hoy, queremos hablarles de un concepto novedoso que se ha observado en dos pacientes pedi\u00e1tricos: el S\u00edndrome Asociado a la Neuropsiquiatr\u00eda de la Varicella (VANS). Este s\u00edndrome se hipotetiza que es el resultado de la reactividad autoinmune, provocada por una imitaci\u00f3n […]<\/p>\n","protected":false},"author":1530,"featured_media":114119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257],"tags":[],"class_list":["post-10914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sistema-inmune"],"_links":{"self":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/users\/1530"}],"replies":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/comments?post=10914"}],"version-history":[{"count":1,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914\/revisions"}],"predecessor-version":[{"id":114162,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/posts\/10914\/revisions\/114162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/media\/114119"}],"wp:attachment":[{"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/media?parent=10914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/categories?post=10914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/test.eneviahealth.com\/en\/wp-json\/wp\/v2\/tags?post=10914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}