Genes involved in regulating energy expenditure, appetite, and fat metabolism play an important role in weight regulation. In fact, between 40% and 80% the variation in body weight is due to genetic factors. This helps explain why not everyone gains or loses weight following the same diet, despite being exposed to similar environments. Identifying an individual's responsiveness to diet and lifestyle modification for weight management can be extremely advantageous.
Genetics determines an individual's susceptibility to obesity when exposed to an unfavorable environment. It also explores how a person responds to diet and exercise.
While healthy nutrition can in certain cases result in weight loss, this depends on many factors. The Genetic Metabolism Test provides a tailored nutrition and exercise program. Healthy eating and exercise can result in weight loss, but this is not guaranteed.
Clinical value
- Provides weight management strategies based on genetic makeup.
- Provides motivation to people with the goal of losing weight.
- Provides an understanding of why previous weight management programs may have failed.
- Provides information on what type of diet (i.e., Mediterranean-style, low-carbohydrate, low-fat diet) may be most suitable for an individual to manage weight, depending on genotype.
DNA diet test report provides:
- The level of impact of any genetic variants identified.
- An explanation of its impact on weight control.
- Appropriate nutritional and lifestyle recommendations. This includes weight management priorities, diet plan principles, exercise planning, and how to calculate MET hours.
Test for: Genes that affect metabolism, insulin sensitivity, satiety, and eating behavior.
Analytes measured:
FABP2 Absorption and Metabolism: It influences the absorption and metabolism of fats. PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism. ADRB2: Involved in the mobilization of fat from fat cells for energy, in response to catecholamines. APOA5: It plays an important role in the regulation of plasma triglycerides. Fat metabolism, obesity and satiety APOA2: an apolipoprotein abundant in HDL. It plays a complex role in lipoprotein metabolism, insulin resistance, obesity, and susceptibility to atherosclerosis. Regulation of metabolism and eating behavior MC4R: a strong candidate gene for obesity, significantly associated with energy intake and expenditure. Insulin Sensitivity and Regulation of Energy Intake FTO: It is involved in the regulation of arousal, appetite, temperature, autonomic function and the endocrine system. TCF7L2: Regulates blood glucose homeostasis, influencing both insulin secretion and sensitivity. Responsiveness to ADBR3 exercise: Involved in the regulation of lipolysis that influences metabolism. Circadian Rhythms CLOCK: An essential regulatory arm of the biological clock, involved in metabolic regulation. Fat storage PLIN: influences diet-induced obesity. TNF-A inflammation: TNFα is a proinflammatory cytokine, secreted by both macrophages and adipocytes, that has been shown to disrupt whole-body glucose homeostasis and has been implicated in the development of obesity, obesity-related insulin resistance, and dyslipidemia. . Carbohydrate sensitivity and eating behavior TAS1R2: It is believed to contribute to interindividual variation in sugar consumption. SLC2A2 (GLUT2): It influences the first step in glucose-induced insulin secretion, affecting both food intake and regulation. DRD2: Midbrain dopamine circuits may play an important role in both addiction and normal eating behavior as they are involved in reward processing, particularly dopaminergic signaling through dopamine receptor 2 (DRD2).
Privacy Policy:
The DNA and original sample material are destroyed after 3 months, so that no names or other identifiers remain on the samples. Samples are analyzed only for the SNPs included in DNALife tests, and no other investigations or analyzes are performed without separate permission from the patient. We do not give or sell the results to third parties.
