Intestinal Permeability Zonulina in feces, Calderón

Analysis to assess leaky gut syndrome. This test evaluates the amount of Zonulin protein in feces to diagnose the degree of intestinal permeability of the patient. Zonulin is a protein found naturally in our body. Its function is based on the activation of the openings of the intercellular junctions allowing the absorption of nutrients. An excess of this protein means that cell junctions remain open. This prolonged opening causes an absorption of substances that in a normal situation should not be absorbed. The zonulin stool test is an non-invasive, fast and safe test. If levels of zonulin considered normal are obtained, it is understood that the intestinal mucosa has normal permeability.

A increased intestinal permeability It is due to alterations of the villi and microvilli that are part of the intestinal epithelium composed of a monocellular layer and, above all, to alterations of the intercellular spaces of that intestinal epithelium. This alteration causes the massive entry of bacterial or food antigens, pathogens, toxins and semi-digested food molecules (peptides, lipids, polysaccharides,...)

The repeated introduction of food antigens through the intestinal mucosa could be responsible for immune responses mediated by IgG or IgE antibodies. resulting in a chronic inflammatory reaction that can explain different pathologies: various inflammatory diseases, autoimmune diseases, allergies, etc., which can be clinically manifested by very varied symptoms: eczema, asthma, colitis, joint and/or muscle pain, headaches, abdominal swelling, diarrhoea, Crohn's, halitosis, etc.