CentoArray: key advantages
HIGH RESOLUTION AND WIDE COVERAGE. Optimized probe spacing, focusing on exonic regions to provide the best coverage of cytogenetic disease variants.
CONTENT FOCUSED ON DISEASES. Platform designed to represent the latest clinical and genetic knowledge with more than 4800 relevant cytogenic genes based on ClinGen, DDG2P, ClinVar, PharmGKB, NHGRI-EBI and GWAS databases.
QUALITY TESTING WITH A WIDE RANGE OF SAMPLE TYPES. Delivering high-quality testing across a wide range of samples including CentoCard®, EDTA blood, ready-to-use DNA, buccal swab, chronic villus, and amniotic fluid.
When is CentoArray recommended?
- As a first-step test for unexplained developmental delays, intellectual disabilities, autism spectrum disorders, and/or multiple congenital malformations
- For extremely large gene deletion/duplication analysis where large deletions involving large gene segments, flanking intergenic regions or neighboring genes are frequently reported.
- To diagnose uniparental disomy (UPD) and regions exhibiting loss/absence of heterozygosity (LOH)
- Together with whole exome sequencing to complement large CNVs. CentoArray can be ordered as a step-by-step analysis after CentoXome or together as a one-step approach.
Features and performance
| Characteristics |
Genome-wide cytogenetic analysis to detect structural aberrations, such as CNV, chromosomal imbalances, LOH, UPD, and mosaicism. |
| markers t
otal (polymorphic) |
1.8 million SNP markers |
| CNV detection resolution |
>25kb for copy number loss
>200kb for copy count gain |
| AOH/LOH detection |
>3 MB |
| Mosaicism detection |
Up to 30% |
| Exon level resolution for |
~4800 relevant cytogenic genes |
| Sample requirements |
CentoCard, EDTA blood, |
If you want to download the test results files you took, you must do so within one month of receiving them. Otherwise, the laboratory will charge you an additional cost for the download service.
